Nobel Prize for Medicine Awarded for Research on 'Biological Clocks'

Herbert Rhodes
October 3, 2017

The post Nobel Prize Awarded for Biological Clock Research appeared first on InvestorPlace.

Three American scientists received the 2017 Nobel Prize in Physiology or Medicine for their research on the work of internal biological clocks in organisms.

BERLIN-Three scientists who made key discoveries on the workings of our internal clock have been awarded this year's Nobel Prize for Physiology or Medicine.

The awardees' work stems back to 1984, when Mr Rosbash and Mr Hall, who was then also at Brandeis, along with Mr Young isolated the "period gene" in fruit flies.

Michael Young has finally identified a third gene, doubletime, which controls the oscillation frequency by delaying the accumulation of PER. All three worked on the fruit fly Drosophila melanogaster to uncover the molecular pathways that control the day-night cycle in many animals, including humans. Professor Foster said he was very happy that three United States experts had won Nobel prize, and y deserved this award as first to explain how Hall, Rosbach and Young's body clock worked, and added: "We have a whole molecular clock They showed how y work in animal kingdom".

The laureates went on to identify additional proteins required for the activation of the period gene, as well as for the mechanism that allows light to synchronise the clock.

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Understanding of the clockwork is important because it regulates critical functions such as behaviour, hormone levels, sleep, body temperature and metabolism. Hall and Rosbash also discovered the protein theperiodgeneencoded, which appeared to build up during the night and degrade during the day on a circadian rhythm.

He told the BBC he was "very delighted" that the USA trio had won, saying they deserved the prize for being the first to explain how the system worked. "Young were able to peek inside our biological clock and elucidate its inner workings", it added. Young works out of Rockefeller University in NY.

It's a roughly 24-hour cycle in the physiological processes of living beings, including plants and animals. "You are kidding me", Rosbash said this morning after he was called and notified of the honor, Thomas Perlmann, the Nobel Commitee's secretary, told journalists this morning.

Professors Hall and Rosbash are researchers at Brandeis University and Professor Young comes from The Rockefeller University.

Michael Hastings, a scientist at the U.K. Medical Research Council, said the discoveries by the 2017 Nobel Medicine winners had opened up a whole new field of study for biology and medicine.

If PER is more stable then the clock ticks more slowly, if it is less stable then it runs too fast.

Other reports by TheSundaySentinel

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